Anti-inflammatory drugs and intermediary metabolism

Nonsteroidal anti-inflammatory drugs.

Non-steroidal anti-inflammatory drugs (NSAIDs) are usually defined as those agents that inhibit one or more reactions involved in the production of prostaglandins and thromboxanes, important mediators of the inflammatory process in many organs and tissues. They find use in horses in the supportive treatment of a variety of systemic states and painful musculoskeletal or soft tissue conditions. T...

Disturbance of lysosomal glycogen metabolism by liposomal anti-alpha-glucosidase and some anti-inflammatory drugs.

The size-distribution of liver glycogen was shown to be distinctly affected by the anti-inflammatory drugs salicylate and indomethacin. By measurement of the incorporation of radioactive glucose into glycogen, salicylate was shown to have a depressing effect on overall liver glycogen metabolism. These effects appear to arise from the stabilizing of the lysosome by the drugs. The incorporation, ...

Intermediary Metabolism

Intermediary metabolism.

Caenorhabditis elegans has orthologs for most of the key enzymes involved in eukaryotic intermediary metabolism, suggesting that the major metabolic pathways are probably present in this species. We discuss how metabolic patterns and activity change as the worm traverses development and ages, or responds to unfavorable external factors, such as temperature extremes or shortages in food or oxyge...

Anti-Inflammatory Activity of a Selection of Antidepressant Drugs

      Anti-inflammatory activity has been reported for a few of antidepressant drugs and in contrary sertraline has potentiated inflammation. In this study, anti-inflammatory effect of a collection of antidepressant drugs belonging to different classes was evaluated to help a rational selection of these drugs in disease conditions such as association of depression or anxiety with inflammatory d...